Potent Inhibition of Hepatitis C Virus RNA Replication in vitro 2 3 4 Running Title : 5 SCY - 635 Inhibits HCV RNA Replication in vitro
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چکیده
SCY-635: A Novel Non-Immunosuppressive Analog of Cyclosporin A that Exhibits 1 Potent Inhibition of Hepatitis C Virus RNA Replication in vitro 2 3 4 Running Title: 5 SCY-635 Inhibits HCV RNA Replication in vitro 6 7 8 Sam Hopkins, 1* Bernard Scorneaux, 1 Zhuhui Huang, 3 Michael G. Murray, 3 Stephen 9 Wring, 1 Craig Smitley, 1 Richard Harris, 1 Frank Erdmann, 2 Gunter Fisher, 2 Yves Ribeill 1 10 11 12 13 Scynexis, Inc., Durham, North Carolina, 27713, USA, 1 Max-Planck Research Unit for 14 Enzymology of Protein Folding, Weinbergweg 22, D-06120 Halle/Saale, Germany, 2 15 Southern Research Institute, 431 Aviation Way, Frederick, MD, 21701,USA. 3 16 17 18 19 Footnote 20 *Corresponding author. Mailing address: Scynexis, Inc., 3501C Tricenter Boulevard, 21 Durham, North Carolina, 27713. Phone: 1 (919) 544-8640. Fax: 1 (919) 544-8697. E22 mail: [email protected]. 23 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00660-09 AAC Accepts, published online ahead of print on 23 November 2009
منابع مشابه
The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes.
The nonimmunosuppressive cyclophilin (Cyp) inhibitor SCY-635 blocks hepatitis C virus (HCV) replication both in vitro and in vivo and represents a novel potent anti-HCV agent. However, its mechanism of action remains to be fully elucidated. A growing body of evidence suggests that cyclophilin A (CypA) is absolutely necessary for HCV replication and that the HCV nonstructural 5A (NS5A) protein s...
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تاریخ انتشار 2009